- Which factor does not impact the complexity of an incident?: Assignment, uk
- You are applying for a job as a junior in-house lawyer at a fashion house. To evaluate your expertise: Consumer and Intellectual Property law Assignment, UOL, UK
- QSP7BEC: Explains the need to update the cost advice from 2019 identifying reasons with examples: Building Economics Assignment, UCEM, UK
- Identify how you have applied OB theory, learned during the module and to develop your knowledge: Organisational behaviour Assignment, OU, UK
- COMP6029: Computer Science and Electronic Engineering related subjects generally use the IEEE referencing style: Network Systems Course Work, UOS, UK
- Describe internal governance procedures used within own organisation: Leadership and Management for Adult Care Assignment, CIPD, UK
- Select an organization of choice but of Pakistan’s origin. The size of selected organization: 30 Resource And Talent Planning (Level 5) Assignment, OU, UK
- You are required to undertake an empirical project involving the analysis: The Social protection Survey Assignment, UOS, UK
- Explain what is meant by restrictive practices, restraint, deprivation of liberty LZ, best-interest decisions: Healthcare Assignment, BCU, UK
- Identify the key provisions of legislation, codes of practice and policies regarding mental: Healthcare Assignment, BCU, UK
- Review the benefits of coaching and mentoring relationships to both parties: Leadership and Management Assignment, UL, UK
- Analyze the difference between coaching and mentoring, giving examples of how each process: Leadership and Management Assignment, UL, UK
- Evaluate ways to address challenges arising during professional supervision: Leadership and Management Assignment, UL, UK
- Analyse factors that can result in a power imbalance in professional supervision and how to address them: Leadership and Management Assignment, UL, UK
- Evaluate how supervision can be used alongside appraisal and professional development processes: Leadership and Management Assignment, UL, UK
- Describe how external and internal factors influence practice and can be used within professional supervision objectives: Leadership and Management Assignment, UL, UK
- Explain why the well-being of the supervisee should be included within effective supervision: Leadership and Management Assignment, UL, UK
- Analyze how effective supervision can protect the supervisor and the organization: Leadership and Management Assignment, UL, UK
- Analyze how effective supervision should be used to support and protect: • the supervisee: Leadership and Management Assignment, UL, UK
- Compare different supervision activities and processes which can be used in adult care: Leadership and Management Assignment, UL, UK
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for: Medicinal Chemistry Assignment, UniS, UK
University | University Of Surrey (UniS) |
Subject | Medicinal Chemistry |
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for. Your team has already found a compound that can moderate the activity of the kinase of interest.
- Using this information, use AutoDockTools and Autodock Vina to dock your compound with the kinase of interest. Your report should include
- A brief explanation of how you determine the search area for the docking, accompanied by a suitable picture to show where the search box is located with respect to the kinase in your docking.
You can click “Ligand Interaction” which will bring you to a new page displaying where and how a drug molecule interacts with the kinase. You can use your mouse to rotate and zoom in/out to help you visualize the binding site.
Once you have a good understanding of where the binding site should be, you need to adjust the dimensions, scaling factor, and the center of the search box in AutoDockTools based on this information. You need to make sure you define the search box correctly in your conf.txt file. - Description of possible interactions between your compound and the kinase that you have identified after docking, accompanied by a suitable picture and labeling to highlight the interactions.
- A table to show the binding affinity of your compound and the kinase from docking.
- Based on the results from the molecular docking, and also using your knowledge of medicinal chemistry, make FIVE changes you would make to the molecule in order to probe SAR and increase binding efficiency. Your answer should be a maximum of ONE A4 page in length, should concisely describe why you are making those changes, and should include chemical drawings of your hit compound and subsequent analogs in order to visualize those changes.
Buy Answer of This Assessment & Raise Your Grades
Answer