- MN0493: Report the major points of your discussions with the client. This should include the construction of the portfolios: Investments and Risk Management Course Work, NUN, UK
- BUSI 1475: Your task is to identify and select an article from the BBC News website (news.bbc.co.uk): Management in a Critical Context Course Work, UOG, UK
- UMACTF-15-M: You have recently been appointed as a Financial Analyst for a leading investment bank in London: Corporate Financial Strategy Course Work, UWE, UK
- BAM5010: choose an organisation and make some recommendations for the delivery: Work Based Project Course Work, UOB, UK
- You are required to calculate ratios for Fresh Farms Ltd: financial Course Work, UK
- Understand the legal, ethical and theoretical context for health, safety and risk management: leadership and Management Course Work, UK
- P3 Describe the types of training and development used by a selected business: BTEC Business Extended Diploma Pearson Course Work, UK
- Describe how a selected business identifies training needs: BTEC Business Extended Diploma Pearson Course Work, UK
- Discuss your chosen business, background information and why you have chosen that business: BTEC Business Extended Diploma Pearson Course Work, UK
- Activity 7: Risk management in an organisation should be both sensible and proportionate to the level of risk involved: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Activity 6: Reviewing health and safety performance Critique your chosen organisation’s health and safety: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Activity 5: Management of contractors Review how your chosen organisation selects contractors and manages them while they are on site: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Activity 2: Preparing a brief research report on approaches to worker consultation: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Create an organisational risk profile for your chosen organisation: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Explain the differences between learning requirements and continuous professional development: Leadership and Management Assignment, UL, UK
- What steps, component parts and enabling tools would you use to develop a therapy: Advanced therapeutic medicinal products Course Work, TUM, UK
- CS3DS19: Construct a KNIME workflow to understand the data characteristics and quality, report: Data Science Algorithms and Tools Course Work, UOW, UK
- Explain how principles of support are implemented in health and social care practice: Diploma In Health And Social Care Level 5 Course Work, UK
- The UK Manufacturing UK LTD is facing an array of issues that require a sound understanding: Management Decision Making Assignment, USM, UK
- Identify sources of information and guidance about how to support a child or young person: child care diploma level 3 Course Work, OU, UK
Neurodevelopmental disorders encompass a wide range of conditions with a genetic component from ADHD: Genetic in Molecular Medicine Course Work, KCL, UK
University | King's College London (KCL) |
Subject | Genetic in Molecular Medicine |
Neurodevelopmental disorders encompass a wide range of conditions with a genetic component from ADHD to aspects of autism. Following large-scale genome sequencing projects, 125 genes have been identified that are associated with this category of disorder. Common processes affected by these genes can be determined by GO-term analysis. But to make the analysis more stringent, filters can be applied.
First, housekeeping genes, which by definition are expressed in all cell types, are removed from the list and then genes that are common to the NDD and ExAC lists can be selected. The ExAC list is a list of genes whose sequence is highly conserved over more than 60 000 human genome sequences suggesting that they have a highly significant function.
- Generate a Venn diagram to identify the number of NDD genes that are common to the ExAC list but which are not found in the housekeeping list of genes. This constitutes the refined NDD analysis list.
- Using a GO-term Molecular Function enrichment analysis of the refined NDD analysis list, present a Table to show the 4 top-level GO-terms with highest the fold-enrichment score and also list the P-value for each.
- Give a brief description of the activity of one of the genes that are common to the two top-level Molecular Function GO terms with the highest fold-enrichment score.
- Put the genes of the NDD analysis list into STRING and select settings for Experiments and Databases only and medium confidence (0.400). Hide disconnected nodes and protein structures and highlight the hub nodes that are associated with GO-042393 histone binding.
Do You Need Assignment of This Question
Looking for a reliable and professional dissertation writing service in the UK? Look no further than Students Assignment Help UK! Our team of experienced and highly qualified writers is dedicated to helping students achieve academic success by providing top-notch dissertation writing assistance. We pride ourselves on delivering original and plagiarism-free work that is tailored to your specific needs and deadlines. So why wait? Contact us today and take the first step towards academic success!